2-methyl-3-benzyl-5-fluoroindole

Base Information

Chemical Name:2-methyl-3-benzyl-5-fluoroindole
CAS No.:1310681-98-1
Molecular Formula:C₁₆H₁₄FN
Molecular Weight:239.292
Hs Code.:

Synonyms:2-methyl-3-benzyl-5-fluoroindole

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Chemical Property of 2-methyl-3-benzyl-5-fluoroindole

Chemical Property:

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Technology Process of 2-methyl-3-benzyl-5-fluoroindole

There total 1 articles about 2-methyl-3-benzyl-5-fluoroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 399-72-4
5-fluoro-2-methyl-1H-indole

: 100-52-7
benzaldehyde

: 1310681-98-1
2-methyl-3-benzyl-5-fluoroindole

Guidance literature:: With 5% Pd(II)/C(eggshell); hydrogen; trifluoroacetic acid; In dichloromethane; at 0 ℃; under 760.051 Torr;
DOI:10.1016/j.tetlet.2011.03.099

Reference yield:

: 1310681-98-1
2-methyl-3-benzyl-5-fluoroindole

: (-)-5-fluoro-2-methyl-3-benzylindoline

: 1304141-58-9
(-)-5-fluoro-2-methyl-3-benzylindoline

Guidance literature:: With C₄₆H₄₁F₃O₂P₂Pd; hydrogen; toluene-4-sulfonic acid; In dichloromethane; 2,2,2-trifluoroethanol; at 20 ℃; for 24h; under 36201.3 Torr; Overall yield = 93 %; Autoclave; Glovebox;
DOI:10.1021/ja502020b

Reference yield:

: 1310681-98-1
2-methyl-3-benzyl-5-fluoroindole

: 104-55-2
3-phenyl-propenal

: C₂₅H₂₀FNO

: C₂₅H₂₀FNO

Guidance literature:: With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; palladium diacetate; benzoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chloroform; at 50 ℃; for 72h; stereoselective reaction; Inert atmosphere; Schlenk technique; Molecular sieve;
DOI:10.1021/acs.orglett.7b03251