Technology Process of (R)-2-(2,4-difluorophenyl)but-3-ene-1,2-diol
There total 5 articles about (R)-2-(2,4-difluorophenyl)but-3-ene-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; C23H28NO2P; water; phenylboronic acid;
In
tetrahydrofuran; water;
at 40 ℃;
for 48h;
Inert atmosphere;
DOI:10.1021/jacs.7b04759
- Guidance literature:
-
(R)-4-(2,4-difluorophenyl)-4-vinyl-1,3-dioxolane;
With
[2,2]bipyridinyl; trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at 0 ℃;
for 0.5h;
With
hydrogenchloride;
In
diethyl ether; dichloromethane; water;
at 20 ℃;
for 2h;
DOI:10.1002/anie.201403754
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine / tetrahydrofuran; water / 15 h / 20 °C / Schlenk technique
4.1: trimethylsilyl trifluoromethanesulfonate; [2,2]bipyridinyl / dichloromethane / 0.5 h / 0 °C
4.2: 2 h / 20 °C
With
pyridine; [2,2]bipyridinyl; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; trimethylsilyl trifluoromethanesulfonate; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1002/anie.201403754
