145240-42-2

Usage

Uses

Used in Pharmaceutical Industry:
2',4'-Difluoro-2-hydroxyacetophenone is used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis and other inflammatory conditions. It is effective in reducing pain and inflammation by inhibiting the production of prostaglandins.
Used as an Analgesic:
2',4'-Difluoro-2-hydroxyacetophenone is used as an analgesic to provide relief from pain, making it suitable for managing mild to moderate pain associated with various conditions.
Used as an Antipyretic:
2',4'-Difluoro-2-hydroxyacetophenone is used as an antipyretic to reduce fever, helping to lower body temperature in cases of elevated temperatures due to illness or inflammation.
Used in Long-term Pain Management:
Due to its long half-life and well-tolerated nature, 2',4'-Difluoro-2-hydroxyacetophenone is used for long-term pain management, allowing for less frequent dosing and providing sustained relief from chronic pain conditions.

Upstream product

• 122263-03-0 2-Acetyloxy-1-(2,4-difluorophenyl)ethanone 
• 50-00-0 formaldehyd 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 364-83-0 2',4'-difluoroacetophenone 
• 67-56-1 methanol 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 

Downstream Products

• 123365-29-7 1-(2,4-Difluoro-phenyl)-2-methoxymethoxy-ethanone 
• 182482-31-1 1-(2,4-Difluoro-phenyl)-2-(tetrahydro-pyran-2-yloxy)-ethanone 
• 182482-28-6 2-(tert-Butyl-dimethyl-silanyloxy)-1-(2,4-difluoro-phenyl)-ethanone 
• 123365-49-1 1-{(S)-[(R)-2-(2,4-Difluoro-phenyl)-oxiranyl]-methylsulfanyl-methyl}-1H-[1,2,4]triazole 
• 123365-49-1 1-{(R)-[(R)-2-(2,4-Difluoro-phenyl)-oxiranyl]-methylsulfanyl-methyl}-1H-[1,2,4]triazole 
• 123365-41-3 (2S,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-3-[1,2,4]triazol-1-yl-propane-1,2-diol 
• 123365-41-3 (2S,3R)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-3-[1,2,4]triazol-1-yl-propane-1,2-diol 
• 123365-34-4 (1S,2S)-2-(2,4-Difluoro-phenyl)-3-methoxymethoxy-1-methylsulfanyl-1-[1,2,4]triazol-1-yl-propan-2-ol 
• 123365-34-4 (1R,2S)-2-(2,4-Difluoro-phenyl)-3-methoxymethoxy-1-methylsulfanyl-1-[1,2,4]triazol-1-yl-propan-2-ol 
• 123364-90-9 (1S,2S)-2-(2,4-Difluoro-phenyl)-1-methylsulfanyl-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol 
• 123364-90-9 (1R,2S)-2-(2,4-Difluoro-phenyl)-1-methylsulfanyl-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol 
• 1202852-66-1 2-(2,4-difluorophenyl)but-3-ene-1,2-diol 
• 1610616-81-3 4-(2,4-difluorophenyl)-4-vinyl-1,3-dioxolan-2-one 
• 1610617-00-9 (R)-4-(2,4-difluorophenyl)-4-vinyl-1,3-dioxolane 

Relevant academic research and scientific papers

Chiral Bidentate Phosphoramidite-Pd Catalyzed Asymmetric Decarboxylative Dipolar Cycloaddition for Multistereogenic Tetrahydrofurans with Cyclic N-Sulfonyl Ketimine Moieties

An asymmetric [3 + 2] cycloaddition of vinyl ethylenecarbonates (VECs) and (E)-3-arylvinyl substituted benzo[d] isothiazole 1,1-dioxides has been developed using the Pd complex of a bidentate phosphoramidite (Me-BIPAM) as the catalyst, providing a wide variety of chiral multistereogenic vinyltetrahydrofurans in good yields with excellent diastereo- and enantioselectivities (up to >20:1 dr, 99% ee).

Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes

A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.

Vinylethylene Carbonates as α,β-Unsaturated Aldehyde Surrogates for Regioselective [3 + 3] Cycloaddition

Herein, we report a novel stepwise addition-controlled ring size method, to access tetrahydropyrimidines through an operationally simple [3 + 3] cycloaddition of vinylethylene carbonates with triazinanes. Interestingly, we could also use this method for a [3 + 3] oxidative cycloaddition, which allows the facile synthesis of polysubstituted terphenyls under mild conditions. Mechanistic studies suggest that vinylethylene carbonates could generate α,β-unsaturated aldehydes as 3-carbon synthons for cycloaddition via a combination process of Pd-catalyzed decarboxylation and β-H elimination.

Spiro[indene-1,4′-oxa-zolidinones] Synthesis via Rh(III)-Catalyzed Coupling of 4-Phenyl-1,3-oxazol-2(3 H)-ones with Alkynes: A Redox-Neutral Approach

Transition-metal-catalyzed C-H activation synthesis of heterocyclic spiro[4,4]nonanes has persistently witnessed the use of additional stoichiometric transition-metal oxidant when employing C=C bond as the spiro ring closure site. Herein, we have addressed the issue by reporting a redox-neutral strategy for spiro[indene-1,4′-oxa-zolidinones] synthesis via Rh(III)-catalyzed coupling of 4-phenyl-1,3-oxazol-2(3H)-ones with alkynes. The synthesis features a broad substrate scope and high regiospecificity.

Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates

Here, we report a palladium-catalyzed controllable cyclization of vinyl ethylene carbonates that proceeds through formal migration [2+3] and [5+2] cycloadditions, respectively, under mild conditions. The transformation described here affords a series of synthetically versatile 5,7-membered N-heterocycles which are found in natural products and pharmaceuticals with biological and medicinal properties.

Enzyme catalyzed hydroxymethylation of aromatic aldehydes with formaldehyde. Synthesis of hydroxyacetophenones and (S)-benzoins

Benzaldehyde lyase from the Pseudomonas Fluorescens catalyzed reaction of aromatic aldehydes with formaldehyde providing 2-hydroxy-1-arylethan-1-one in high yields via an acyloin linkage. Kinetic resolution of rac-benzoins with formaldehyde providing (S)-benzoins and 2-hydroxy-1-arylethan-1-one via C-C bond cleavage and a bond formation reaction.

Asymmetric synthesis of SM-9164, a biologically active enantiomer of antifungal agent SM-8668

SM-9164, a biologically active enantiomer of antifungal agent SM-8668, was prepared by asymmetric synthesis in 10 steps in 13% overall yield from commercially available 2-chloro-1-(2,4-difluorophenyl)ethanone. The crucial steps were Katsuki-Sharpless asymmetric epoxidation of the (E)-allylic alcohol and epimerization of the erythro-sulfone to the desired threo-isomer under basic conditions.