2',4'-DIFLUORO-2-HYDROXYACETOPHENONE

Base Information

• Chemical Name: 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE
• CAS No.: 145240-42-2
• Molecular Formula: C8H6 F2 O2
• Molecular Weight: 172.13
• Mol file: 145240-42-2.mol

Synonyms:2',4'-Difluoro-2-hydroxyacetophenone;2',4'-Difluoro-a-hydroxyacetophenone

Chemical Property of 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE

Chemical Property:

• PSA: 37.30000
• LogP: 1.13980

Purity/Quality:

98%min ^*data from raw suppliers

2'',4''-Difluoro-2-hydroxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE

There total 7 articles about 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-Acetyloxy-1-(2,4-difluorophenyl)ethanone (122263-03-0) → 1-(2,4-difluorophenyl)-2-hydroxyethanone (145240-42-2)

Guidance literature:

With hydrogenchloride; In methanol; at 40 ℃; for 5h;

DOI:10.1246/bcsj.69.2625

Reference yield: 15.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,4-difluorobenzaldehyde (1550-35-2) → 1-(2,4-difluorophenyl)-2-hydroxyethanone (145240-42-2)

Guidance literature:

With potassium phosphate buffer; thiamine diphosphate; magnesium sulfate; benzaldehyde lyase from Pseudomonas fluorescens; In dimethyl sulfoxide; at 37 ℃; pH=7.0; Enzymatic reaction;

DOI:10.1016/j.tet.2004.06.015

Reference yield:

2',4'-difluoroacetophenone (364-83-0) → 1-(2,4-difluorophenyl)-2-hydroxyethanone (145240-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / diethyl ether / 0 - 20 °C

2: sodium formate / methanol / Reflux

With bromine; sodium formate; In methanol; diethyl ether;

DOI:10.1039/C8CC06945J

upstream raw materials:

2-Acetyloxy-1-(2,4-difluorophenyl)ethanone

formaldehyd

2,4-difluorobenzaldehyde

2-chloro-1-(2,4-dichlorophenyl)ethanone

Downstream raw materials:

1-(2,4-Difluoro-phenyl)-2-methoxymethoxy-ethanone

1-(2,4-Difluoro-phenyl)-2-(tetrahydro-pyran-2-yloxy)-ethanone

N-[1-(2,4-difluoro-phenyl)-2-methoxymethoxy-vinyl]-acetamide

(R)-2-(2,4-difluorophenyl)but-3-ene-1,2-diol

Refernces

• 1、 Chen, Yuehua,Deng, Hao,Gao, Xing,Guo, Hongchao,Jiang, Feng,Wang, Wei,Wu, Yongjun,Zhu, Dongyu. "Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes". supporting information. p. 7158 - 7163. Retrieved 2020/10/02.
• 2、 Liu, Zhongsu,Zhang, Wenjing,Guo, Shan,Zhu, Jin. "Spiro[indene-1,4′-oxa-zolidinones] Synthesis via Rh(III)-Catalyzed Coupling of 4-Phenyl-1,3-oxazol-2(3 H)-ones with Alkynes: A Redox-Neutral Approach". . p. 11945 - 11957. Retrieved 2019/10/02.