(S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

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Chemical Name:(S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile
CAS No.:180072-50-8
Molecular Formula:C₃₉H₄₆N₂O₆Si
Molecular Weight:666.89
Hs Code.:

Synonyms:(S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

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Chemical Property of (S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

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Technology Process of (S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

There total 2 articles about (S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 100-39-0
benzyl bromide

: 180072-48-4
(S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

: 180072-50-8
(S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/0040-4039(96)00819-2

Reference yield:

: (3R,5S)-7,8-Dimethoxy-3-phenyl-5-(3,4,5-trimethoxy-phenyl)-2,3,10,10a-tetrahydro-5H-oxazolo[3,2-b]isoquinoline

: 180072-50-8
(S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / aluminium chloride / toluene / 12 h / Ambient temperature

2: 70 percent / LDA / tetrahydrofuran / -78 °C

With aluminium trichloride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1016/0040-4039(96)00819-2

Reference yield:

: 180072-50-8
(S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

: (R)-2-[(1S,3R)-3-Benzyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 0.25 h / Ambient temperature

2: sodium borohydride, trifluoroacetic acid / tetrahydrofuran / 30 h / 0 °C

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1016/0040-4039(96)00819-2