(S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

Base Information

• Chemical Name: (S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile
• CAS No.: 180072-48-4
• Molecular Formula: C₃₂H₄₀N₂O₆Si
• Molecular Weight: 576.765

Synonyms:(S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

Chemical Property of (S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

Chemical Property:

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Technology Process of (S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

There total 1 articles about (S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

trimethylsilyl cyanide (7677-24-9) + (3R,5S)-7,8-Dimethoxy-3-phenyl-5-(3,4,5-trimethoxy-phenyl)-2,3,10,10a-tetrahydro-5H-oxazolo[3,2-b]isoquinoline → (S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile (180072-48-4)

Guidance literature:

With aluminium trichloride; In toluene; for 12h; Ambient temperature;

DOI:10.1016/0040-4039(96)00819-2

Reference yield: 70.0%

benzyl bromide (100-39-0) + (S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile (180072-48-4) → (S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile (180072-50-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/0040-4039(96)00819-2

Reference yield: 70.0%

(S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile (180072-48-4) + methyl iodide (74-88-4) → (S)-6,7-Dimethoxy-3-methyl-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile (180072-49-5)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/0040-4039(96)00819-2

upstream raw materials:

trimethylsilyl cyanide

Downstream raw materials:

(S)-3-Benzyl-6,7-dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

(S)-6,7-Dimethoxy-3-methyl-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

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