2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid

Base Information

• Chemical Name: 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid
• CAS No.: 668421-30-5
• Molecular Formula: C₃₂H₃₂N₂O₈
• Molecular Weight: 572.615
• Mol file: 668421-30-5.mol

Synonyms:2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid

Chemical Property of 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid

There total 4 articles about 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chlorooxalate (35249-73-1) + 2-[4-(2-acetylamino-2-allyloxycarbonylethyl)-2-ethylphenylamino]-benzoic acid (592531-95-8) → 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid (668421-30-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm034088d

Reference yield:

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid (402924-97-4) → 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid (668421-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / Cs₂CO₃ / dimethylformamide / 3 h / 20 °C

2: copper(II) acetate / dimethylformamide / 6 h / 90 °C

3: 700 mg / N,N-diisopropylethylamine / dimethylformamide / 20 °C

With copper diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm034088d

Reference yield:

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid allyl ester (402924-98-5) → 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid (668421-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(II) acetate / dimethylformamide / 6 h / 90 °C

2: 700 mg / N,N-diisopropylethylamine / dimethylformamide / 20 °C

With copper diacetate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm034088d

upstream raw materials:

benzyl chlorooxalate

2-[4-(2-acetylamino-2-allyloxycarbonylethyl)-2-ethylphenylamino]-benzoic acid

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid allyl ester

Downstream raw materials:

methyl 2-[(5-{[2-(acetylamino)-3-(4-{2-[(benzhydryloxy)carbonyl][(benzyloxy)(oxo)acetyl]anilino}-3-ethylphenyl)propanoyl]amino}pentyl)oxy]-6-hydroxybenzoate

methyl 2-{4-[(N-acetyl-4-[(carboxycarbonyl)(2-carboxyphenyl)amino]-3-ethylphenylalanyl)amino]butoxy}-6-hydroxybenzoate