5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole

Base Information

Chemical Name:5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole
CAS No.:1193353-33-1
Molecular Formula:C₁₈H₁₅F₃N₂O
Molecular Weight:332.325
Hs Code.:

Synonyms:5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole

Chemical Property:

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Technology Process of 5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole

There total 5 articles about 5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 823-96-1
Trimethylboroxine

: 1193352-82-7
2,4-dibromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole

: 1193353-33-1
5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole

Guidance literature:: With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; Reflux;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1193353-33-1
5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: indium(III) chloride / tetrahydrofuran / 20 °C

2: dichloromethane / 0.02 h / 80 °C

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 60 °C

4: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Reflux

With indium(III) chloride; N-Bromosuccinimide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 149949-30-4
2,6-difluoro-3-methoxybenzaldehyde

: 1193353-33-1
5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: indium(III) chloride / tetrahydrofuran / 20 °C

2: dichloromethane / 0.02 h / 80 °C

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 60 °C

4: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Reflux

With indium(III) chloride; N-Bromosuccinimide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;