4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

Base Information

Chemical Name:4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile
CAS No.:1159735-59-7
Molecular Formula:C₂₄H₂₁Cl₂F₄N₃O₂
Molecular Weight:530.349
Hs Code.:

Synonyms:4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

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Chemical Property of 4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

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Technology Process of 4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

There total 6 articles about 4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159735-57-5
(2S,5R)-2-tert-butyl-3-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-1-(2,2,2-trifluoro-acetyl)-imidazolidin-4-one

: 17201-43-3
4-cyanobenzyl bromide

: 1159735-59-7
4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

Guidance literature:: (2S,5R)-2-tert-butyl-3-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-1-(2,2,2-trifluoro-acetyl)-imidazolidin-4-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 - -5 ℃; for 1.91667h;

4-cyanobenzyl bromide; In tetrahydrofuran; at -10 - 10 ℃; for 2.83333h;

Reference yield:

: 1159735-51-9
[(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 1159735-59-7
4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol; dichloromethane; water / 20 °C

2.1: pivalaldehyde / toluene / 22 h / 50 °C

3.1: triethylamine / 2 h / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 - -5 °C / Inert atmosphere

4.2: -10 - 0 °C

With hydrogenchloride; pivalaldehyde; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

: 1159735-55-3
(2S,5R)-2-tert-butyl-3-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-imidazolidin-4-one

: 1159735-59-7
4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 2 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 - -5 °C / Inert atmosphere

2.2: -10 - 0 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran;