(R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

Base Information

Chemical Name:(R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid
CAS No.:1159735-71-3
Molecular Formula:C₂₁H₁₃Cl₂FN₄O₃
Molecular Weight:459.264
Hs Code.:

Synonyms:(R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

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Chemical Property of (R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

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Technology Process of (R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

There total 14 articles about (R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159735-69-9
(R)‐4‐((1‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐iodo‐3‐methyl‐2‐oxo‐2,3‐dihydro‐1H‐imidazo[1,2‐a]imidazol‐3‐yl)methyl)benzonitrile

: 141-53-7
sodium formate

: 1159735-71-3
(R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

Guidance literature:: sodium formate; With acetic anhydride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

(R)‐4‐((1‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐iodo‐3‐methyl‐2‐oxo‐2,3‐dihydro‐1H‐imidazo[1,2‐a]imidazol‐3‐yl)methyl)benzonitrile; With lithium chloride; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

With hydrogenchloride; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1159735-69-9
(R)‐4‐((1‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐iodo‐3‐methyl‐2‐oxo‐2,3‐dihydro‐1H‐imidazo[1,2‐a]imidazol‐3‐yl)methyl)benzonitrile

: 108-24-7
acetic anhydride

: 1159735-71-3
(R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

Guidance literature:: acetic anhydride; With sodium formate; palladium diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

(R)‐4‐((1‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐iodo‐3‐methyl‐2‐oxo‐2,3‐dihydro‐1H‐imidazo[1,2‐a]imidazol‐3‐yl)methyl)benzonitrile; With lithium chloride; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

Reference yield:

: 1159735-69-9
(R)‐4‐((1‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐iodo‐3‐methyl‐2‐oxo‐2,3‐dihydro‐1H‐imidazo[1,2‐a]imidazol‐3‐yl)methyl)benzonitrile

: 141-53-7
sodium formate

: 108-24-7
acetic anhydride

: 1159735-71-3
(R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

Guidance literature:: sodium formate; acetic anhydride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h; Sealed vessel;

(R)‐4‐((1‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐iodo‐3‐methyl‐2‐oxo‐2,3‐dihydro‐1H‐imidazo[1,2‐a]imidazol‐3‐yl)methyl)benzonitrile; With lithium chloride; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

With hydrogenchloride; In water; ethyl acetate;