(2R,3S)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane

Base Information

Chemical Name:(2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane
CAS No.:146060-99-3
Molecular Formula:C₂₈H₃₃NO₃Si
Molecular Weight:459.66
Hs Code.:

Synonyms:(2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane

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Chemical Property of (2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane

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Technology Process of (2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane

There total 2 articles about (2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 146060-97-1
(2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropan-1-ol

: 75-36-5
acetyl chloride

: 146060-99-3
(2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1039/P19920002813

Reference yield:

: 146060-96-0
methyl (2R*,3S*)-3-benzylamino-2-(dimethylphenylsilyl)-3-phenylpropionate

: 146060-99-3
(2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / LiAlH₄ / diethyl ether / 0 deg C, 10 min, then room temp., 30 min

2: 95 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

With pyridine; lithium aluminium tetrahydride; In diethyl ether; dichloromethane;
DOI:10.1039/P19920002813

Reference yield:

: 146060-99-3
(2R*,3S*)-1-acetoxy-3-(N-benzylacetamido)-2-(dimethylphenylsilyl)-3-phenylpropane

: Acetic acid (2R,3S)-3-(acetyl-benzyl-amino)-2-hydroxy-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) bromine 2.) Et₃N / 1.) CH₂Cl₂, room temp., 2 h 2.) THF, room temp., 1 h

2: 30percent H₂O₂, KF, KHCO₃ / tetrahydrofuran; methanol

With potassium fluoride; dihydrogen peroxide; bromine; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1039/P19920002813