3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol

Base Information

Chemical Name:3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol
CAS No.:211505-56-5
Molecular Formula:C₁₉H₃₀O₁₅S₄
Molecular Weight:626.702
Hs Code.:

Synonyms:3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol

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Technology Process of 3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol

There total 5 articles about 3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 124-63-0
methanesulfonyl chloride

: 211505-55-4
3-deoxy-3-p-methoxyphenyl-4-acetyl-D-mannitol

: 211505-56-5
3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol

Guidance literature:: In pyridine; at 0 - 20 ℃; for 20h;
DOI:10.1080/00397919808004827

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 211505-56-5
3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol

Guidance literature:: Multi-step reaction with 5 steps

1: Mg / CuI / diethyl ether / 0.5 h / -78 °C

2: 40 percent / diethyl ether / 3 h / -78 - 20 °C

3: 95 percent / pyridine / 24 h / 20 °C

4: 79.4 percent / aq. acetic acid / 6 h / 20 °C

5: 70 percent / pyridine / 20 h / 0 - 20 °C

With magnesium; acetic acid; copper(l) iodide; In pyridine; diethyl ether; 1: Grignard reaction / 2: Grignard reaction / 3: Acylation / 4: deprotection / 5: Substitution;
DOI:10.1080/00397919808004827

Reference yield:

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 211505-56-5
3-deoxy-3-p-methoxyphenyl-4-acetyl-1,2,5,6-O-tetramethylsulfonyl-D-mannitol

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / diethyl ether / 3 h / -78 - 20 °C

2: 95 percent / pyridine / 24 h / 20 °C

3: 79.4 percent / aq. acetic acid / 6 h / 20 °C

4: 70 percent / pyridine / 20 h / 0 - 20 °C

With acetic acid; In pyridine; diethyl ether; 1: Grignard reaction / 2: Acylation / 3: deprotection / 4: Substitution;
DOI:10.1080/00397919808004827