N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

Base Information

Chemical Name:N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine
CAS No.:1356054-44-8
Molecular Formula:C₁₉H₁₅FN₆
Molecular Weight:346.367
Hs Code.:

Synonyms:N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

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Chemical Property of N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

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Technology Process of N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

There total 4 articles about N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1356055-13-4
N-cyclopropyl-5-iodopyrimidin-4-amine

: 1356054-68-6
1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid

: 1356054-44-8
N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 90 ℃; for 13h; Inert atmosphere;

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 1356054-44-8
N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 18.33 h / 20 - 185 °C / Inert atmosphere; capped

2: bis(pinacol)diborane; potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 84 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 13 h / 90 °C / Inert atmosphere

With potassium acetate; sodium carbonate; bis(pinacol)diborane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 153034-82-3
[(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde

: 1356054-44-8
N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 18.33 h / 20 - 185 °C / Inert atmosphere; capped

2: bis(pinacol)diborane; potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 84 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 13 h / 90 °C / Inert atmosphere

With potassium acetate; sodium carbonate; bis(pinacol)diborane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide;