(1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one

Base Information

• Chemical Name: (1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one
• CAS No.: 1442476-46-1
• Molecular Formula: C₂₅H₂₁ClN₄O₂
• Molecular Weight: 444.92

Synonyms:(1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one

Chemical Property of (1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one

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Technology Process of (1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one

There total 6 articles about (1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.2%

(E)-4-(2-(8-methylquinazolin-4-yloxy)phenyl)but-3-en-2-one (1442476-82-5) + 5-chloro-4-formyl-1,3-dimethylpyrazole (27006-76-4) → (1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one (1442476-46-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.02.035

Reference yield:

(E)-4-(2-hydroxyphenyl)but-3-en-2-one (6051-53-2) → (1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one (1442476-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 8 h / 30 - 50 °C / Inert atmosphere

2: sodium hydroxide / ethanol; water / 3 h / 20 °C / Inert atmosphere

With potassium carbonate; sodium hydroxide; In ethanol; water; acetonitrile;

DOI:10.1016/j.ejmech.2013.02.035

Reference yield:

4-chloro-8-methylquinazoline (58421-80-0) → (1E,4E)-1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-5-(2-(8-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one (1442476-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 8 h / 30 - 50 °C / Inert atmosphere

2: sodium hydroxide / ethanol; water / 3 h / 20 °C / Inert atmosphere

With potassium carbonate; sodium hydroxide; In ethanol; water; acetonitrile;

DOI:10.1016/j.ejmech.2013.02.035

upstream raw materials:

(E)-4-(2-(8-methylquinazolin-4-yloxy)phenyl)but-3-en-2-one

5-chloro-4-formyl-1,3-dimethylpyrazole

(E)-4-(2-hydroxyphenyl)but-3-en-2-one

4-chloro-8-methylquinazoline

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