Multi-step reaction with 5 steps
1: 1.) 1M n-Bu2BOSO2CF3, Et3N / 1.) CH2Cl2, -10 deg C, 1 h, 2.) CH2Cl2, -78 deg C, 30 min; -10 deg C, 1 h
2: 1.) Na / 1.) r.t., 30 min, 2.) 0 deg C, 3 h
3: 95 percent / RhCl3*3H2O, Aliquat 336, H2 / 1,2-dichloro-ethane; H2O / 24 h / 30 °C / 3677.5 Torr
4: 1.) n-BuLi / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h
5: 1.) (Me2CH)2NH, n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 15 min; to -20 deg C, 30 min
With
rhodium(III) chloride; n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; hydrogen; sodium; Aliquat 336; triethylamine; diisopropylamine;
In
water; 1,2-dichloro-ethane;