((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

Base Information

Chemical Name:((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate
CAS No.:1584715-84-3
Molecular Formula:C₃₆H₄₁F₄N₅O₇
Molecular Weight:731.744
Hs Code.:

((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

Synonyms:((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

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Chemical Property of ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

There total 19 articles about ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.2%

: 1581704-70-2
1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropanecarboxylic acid chloromethyl ester

: 1584713-87-0
(2R,3S)-3-(cyclopropylmethyl)-N-((3S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

: 1584715-84-3
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 24 ℃; for 5h;

Reference yield:

: 1584139-76-3
(2-amino-3-fluorophenyl)(phenyl)methanone

: 1584715-84-3
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C

1.2: 20 °C

2.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C

4.2: 8 - 20 °C

4.3: Lux-Cell₄ / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO₂

5.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 24 °C

With oxalyl dichloride; hydrogen bromide; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1584139-77-4
7-fluoro-3-hydroxy-3-phenylindolin-2-one

: 1584715-84-3
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide / N,N-dimethyl-formamide; water / 1.67 h / 110 - 120 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C

2.2: 20 °C

3.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C

5.2: 8 - 20 °C

5.3: Lux-Cell₄ / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO₂

6.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 24 °C

With potassium hexacyanoferrate(II); oxalyl dichloride; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;