benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

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Chemical Name:benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate
CAS No.:1584715-01-4
Molecular Formula:C₂₃H₁₈FN₃O₃
Molecular Weight:403.413
Hs Code.:

Synonyms:benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

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Chemical Property of benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

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Technology Process of benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

There total 4 articles about benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1584139-76-3
(2-amino-3-fluorophenyl)(phenyl)methanone

: 124676-19-3
2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine

: 1584715-01-4
benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

Guidance literature:: 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine; With oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

(2-amino-3-fluorophenyl)(phenyl)methanone; With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1584139-77-4
7-fluoro-3-hydroxy-3-phenylindolin-2-one

: 1584715-01-4
benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide / N,N-dimethyl-formamide; water / 1.67 h / 110 - 120 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C

2.2: 20 °C

With potassium hexacyanoferrate(II); oxalyl dichloride; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1584715-01-4
benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0.25 h / 0 - 20 °C

2.1: potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide / N,N-dimethyl-formamide; water / 1.67 h / 110 - 120 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C

3.2: 20 °C

With potassium hexacyanoferrate(II); oxalyl dichloride; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;