(2-amino-3-fluorophenyl)(phenyl)methanone

Base Information

• Chemical Name: (2-amino-3-fluorophenyl)(phenyl)methanone
• CAS No.: 1584139-76-3
• Molecular Formula: C₁₃H₁₀FNO
• Molecular Weight: 215.227
• Hs Code.: 2914790090
• Mol file: 1584139-76-3.mol

Synonyms:(2-amino-3-fluorophenyl)(phenyl)methanone

Chemical Property of (2-amino-3-fluorophenyl)(phenyl)methanone

Chemical Property:

• Boiling Point: 381.5±32.0 °C(Predicted)
• Density: 1.236±0.06 g/cm3(Predicted)

Purity/Quality:

99.3% ^*data from raw suppliers

(2-Amino-3-fluorophenyl)(phenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-amino-3-fluorophenyl)(phenyl)methanone

There total 5 articles about (2-amino-3-fluorophenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

phenylmagnesium bromide (100-58-3) + 2-amino-3-fluorobenzonitrile (115661-37-5) → (2-amino-3-fluorophenyl)(phenyl)methanone (1584139-76-3)

Guidance literature:

phenylmagnesium bromide; 2-amino-3-fluorobenzonitrile; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 63.0%

7-fluoro-3-hydroxy-3-phenylindolin-2-one (1584139-77-4) → (2-amino-3-fluorophenyl)(phenyl)methanone (1584139-76-3)

Guidance literature:

With potassium ferrocyanide; sodium hydrogencarbonate; sodium hydroxide; In water; N,N-dimethyl-formamide; at 110 - 120 ℃; for 1.66667h;

Reference yield:

phenylmagnesium bromide (100-58-3) → (2-amino-3-fluorophenyl)(phenyl)methanone (1584139-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.25 h / 0 - 20 °C

2: potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide / N,N-dimethyl-formamide; water / 1.67 h / 110 - 120 °C

With potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

upstream raw materials:

7-fluoro-3-hydroxy-3-phenylindolin-2-one

7-fluoro-1H-indole-2,3-dione

phenylmagnesium bromide

2-amino-3-fluorobenzonitrile

Downstream raw materials:

benzyl 9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

(2S,3R)-2-(cyclopropylmethyl)-N₄-((3S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-N₁-(1-pyrrolidinylmethyl)-3-(3,3,3-trifluoropropyl)succinamide

((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl 1-aminocyclopropanecarboxylate

((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl L-valinate