Chemical Property of Aqupla
Chemical Property:
- Appearance/Colour:Straw yellow powder
- Boiling Point:265.6oC at 760 mmHg
- Flash Point:128.7oC
- PSA：42.01000
- LogP:0.12010
- Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:0
- Exact Mass:305.033937
- Heavy Atom Count:8
- Complexity:44.1
- Purity/Quality:
-
99% *data from raw suppliers
Nedaplatin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C(C(=O)O)O.N.N.[Pt]
- Recent ClinicalTrials:Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell Carcinoma
- Recent NIPH Clinical Trials:A phase II study of biweekly Docetaxel + Nedaplatin in advanced esophageal cancer in patients previously treated with FP and anti-PD-1 antibodies
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Description
Nedaplatin, a novel second generation platinum complex, was marketed
in Japan for the treatment of a variety of cancers including: head and neck, small-cell
and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder,
and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been
reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which
react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and
DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more
active than cisplatin against several solid tumors while sharing less nephro- and
gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by
nedaplatin allows its use in patients with deteriorated renal function.
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Uses
Nedaplatin is a platinum complex that has potent antineoplatic activity.
