Platinum, diamminebis(nitrato-kappaO)-, (SP-4-2)-

Base Information

• Chemical Name: Platinum, diamminebis(nitrato-kappaO)-, (SP-4-2)-
• CAS No.: 41575-87-5
• Molecular Formula: H₆N₄O₆Pt
• Molecular Weight: 353.151
• European Community (EC) Number: 255-445-5
• DSSTox Substance ID: DTXSID90961818
• Mol file: 41575-87-5.mol

Synonyms:41575-87-5;Platinum, diamminebis(nitrato-kappaO)-, (SP-4-2)-;Platinum (II), dinitrodiammine;cis-Diamminedinitratoplatinum;Dinitratodiamminoplatinum(II);cis-Diamminedinitratoplatinum(II);trans-Diamminedinitratoplatinum(II);EINECS 255-445-5;Platinum (II), diamminedinitrato-, cis-;Platinum (II), diamminedinitrato-, trans-;DTXSID90961818;cis-Diamminebis(nitrito-O)platinum;Platinum(2+) nitrate--ammonia (1/2/2);(SP-4-2)-Diamminebis(nitrato-?O)platinum;LS-117701;LS-117702;Platinum, diamminebis(nitrato-.kappa.O)-, (SP-4-2)-;74006-35-2

Chemical Property of Platinum, diamminebis(nitrato-kappaO)-, (SP-4-2)-

Chemical Property:

• Vapor Pressure: 49.8mmHg at 25°C
• Melting Point: >121°C (dec.)
• Boiling Point: 83°Cat760mmHg
• Flash Point: °C
• PSA: 144.24000
• Density: g/cm³
• LogP: 1.21350
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMF (Slightly), Water (Slightly, Sonicated)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 0
• Exact Mass: 352.993528
• Heavy Atom Count: 11
• Complexity: 18.8

Purity/Quality:

99% ^*data from raw suppliers

cis-Diamminedinitratoplatinum ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: N.N.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Pt+2]
• Uses: Synthesis and cytotoxic activity of platinum complex immobilized by branched polyethylene glycol. Platinum diammine complexes are anticancer agents for brain tumors. Synthesis and cytotoxic activity of platinum complex immobilized by branched polyethylene glycol. Platinum diammine complexes are anticancer agents for brain tumors

Technology Process of Platinum, diamminebis(nitrato-kappaO)-, (SP-4-2)-

There total 13 articles about Platinum, diamminebis(nitrato-kappaO)-, (SP-4-2)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cis-diaminediiodoplatinum(II) + silver nitrate → cis-diaminedinitroplatinum(II) (41575-87-5,14286-03-4,74006-35-2)

Guidance literature:

With hydrogenchloride; In water; byproducts: AgCl; addn. of aq. AgNO3 to a suspn. of Pt-complex in water, heating at 70°C in the dark for 30 min; cooling, filtn. through celite, treating with two drops of aq. HCl to check the absence of silver, filtn., evapn. of filtrate to dryness, redissolution of residue in water with heating, filtn., evapn. to dryness, elem. anal.;

Reference yield: 84.0%

cis-diamminediiodoplatinum (II) (13841-96-8,15978-93-5,15978-94-6) + silver nitrate → {Pta2(NO3)2} (74006-35-2,41575-87-5,14286-03-4)

Guidance literature:

In water; for 2h; Inert atmosphere;

DOI:10.1016/j.ica.2014.11.017

Reference yield: 82.0%

cisplatin (15663-27-1) → cis-diaminedinitroplatinum(II) (41575-87-5,14286-03-4,74006-35-2) + cis-diamminechloro(nitrato)platinum(II) (117228-94-1) + cis-{Pt(NH3)2(O1-DMF)Cl}(1+) (128707-47-1,160017-70-9,79084-70-1) + cis-{Pt(NH3)2(O1-DMF)2}(2+) + cis-{Pt(NH3)2(O1-DMF)(NO3)}(1+)

Guidance literature:

With AgNO₃; In N,N-dimethyl-formamide; byproducts: AgCl; reacting AgNO3 with Pt complex in DMF (16 h, in the dark); centrifugation; detected by 195 Pt NMR;

DOI:10.1021/ja00160a044

upstream raw materials:

cisplatin

transplatin

trans-diiododiammineplatinum(II)

nitric acid

Downstream raw materials:

cisplatin

nedaplatin

cis-diamminedibromoplatinum(II)

transplatin

Refernces

• 1、 -. "A novel platinum-based liposome preparation, and its preparation method". Paragraph 0061; 0062. . Retrieved 2017/02/24.
• 2、 Chopade, Suresh M.,Phadnis, Prasad P.,Hodage, Ananda S.,Wadawale, Amey,Jain, Vimal K.. "Synthesis, characterization, structures and cytotoxicity of platinum(II) complexes containing dimethylpyrazole based selenium ligands". supporting information. p. 72 - 80. Retrieved 2015/02/19.