4-methoxybenzoic acid [1,4]dioxan-2-yl ester

Base Information

• Chemical Name: 4-methoxybenzoic acid [1,4]dioxan-2-yl ester
• CAS No.: 1284251-41-7
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol file: 1284251-41-7.mol

Synonyms:4-methoxybenzoic acid [1,4]dioxan-2-yl ester

Chemical Property of 4-methoxybenzoic acid [1,4]dioxan-2-yl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-methoxybenzoic acid [1,4]dioxan-2-yl ester

There total 12 articles about 4-methoxybenzoic acid [1,4]dioxan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + 4-methoxybenzoic acid (100-09-4) → 4-methoxybenzoic acid [1,4]dioxan-2-yl ester (1284251-41-7)

Guidance literature:

With di-tert-butyl peroxide; copper 5,10,15-tris(pentafluorophenyl)corrole; at 120 ℃; for 12h; Schlenk technique;

DOI:10.3987/COM-21-14408

Reference yield: 91.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + 4-methoxy-benzaldehyde (123-11-5) → 4-methoxybenzoic acid [1,4]dioxan-2-yl ester (1284251-41-7)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) acetate monohydrate; In water; at 80 ℃; for 24h;

DOI:10.1039/c4ob00862f

Reference yield: 91.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + p-methoxybenzoylformic acid (7099-91-4) → 4-methoxybenzoic acid [1,4]dioxan-2-yl ester (1284251-41-7)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; at 80 ℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c3ob40748a

upstream raw materials:

1,4-dioxane

4-methoxybenzoic acid

4-methoxy-benzaldehyde

p-methoxybenzoylformic acid

Refernces

• 1、 Majji, Ganesh,Guin, Srimanta,Rout, Saroj K.,Behera, Ahalya,Patel, Bhisma K.. "Cyclic ethers to esters and monoesters to bis-esters with unconventional coupling partners under metal free conditions via sp3 C-H functionalisation". . p. 12193 - 12196. Retrieved 2014.
• 2、 Macías-Benítez, Pablo,Moreno-Dorado, F. Javier,Guerra, Francisco M.. "Microwave-Enhanced Coupling of Carboxylic Acids with Liquid Ketones and Cyclic Ethers Using Tetrabutylammonium Iodide/ t-Butyl Hydroperoxide". . p. 6027 - 6043. Retrieved 2020/05/22.