3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Base Information

Chemical Name:3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile
CAS No.:1600566-51-5
Molecular Formula:C₂₉H₁₉F₂N₅O
Molecular Weight:491.5
Hs Code.:

Synonyms:3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Suppliers and Price of 3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

There total 8 articles about 3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600566-52-6
(2,4-dichloro-3-(3-fluorophenyl)-8-methylquinolin-6-yl)(4-fluorophenyl)(1-methyl-1H-imidazol-5-yl)methanol

: 1600566-51-5
3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos; In N,N-dimethyl acetamide; at 120 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 116332-54-8
4-fluoro-N-methoxy-N-methylbenzamide

: 1600566-51-5
3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.33 h / 20 °C / Cooling with ice

1.2: 20 °C / Cooling with ice

2.1: tetrahydrofuran / 0.03 h / Inert atmosphere; Cooling with acetone-dry ice

2.2: 1.17 h / -78 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos / N,N-dimethyl acetamide / 1.5 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethylmagnesium bromide; zinc; XPhos; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide;

Reference yield:

: 1121-86-4
1-Fluoro-3-iodobenzene

: 1600566-51-5
3-(3-fluorophenyl)-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; copper(l) iodide / 1,4-dioxane / 20 °C / Inert atmosphere

2.1: sodium hydroxide / water / 0.17 h / 65 °C

3.1: trichlorophosphate / 1 h / 70 °C

3.2: 3 h / 105 °C

4.1: tetrahydrofuran / 0.03 h / Inert atmosphere; Cooling with acetone-dry ice

4.2: 1.17 h / -78 °C / Inert atmosphere

4.3: Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos / N,N-dimethyl acetamide / 1.5 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; caesium carbonate; sodium hydroxide; zinc; XPhos; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; water;