2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate

Base Information

• Chemical Name: 2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate
• CAS No.: 1010389-46-4
• Molecular Formula: C₄₄H₇₈O₅Si₂
• Molecular Weight: 743.271

Synonyms:2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate

Chemical Property of 2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate

Chemical Property:

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Technology Process of 2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate

There total 1 articles about 2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.8%

(6S)-6-((1R,3R,7E)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylene-9,10-secoestra-5,7-dien-17-yl)-2-methylene-1,4-heptanediol (1010389-34-0) + pivaloyl chloride (3282-30-2) → 2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate (1010389-46-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 22.5h;

DOI:10.1016/j.bmc.2007.09.017

Reference yield: 99.8%

2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate (1010389-46-4) + (R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) → (1S)-1-[(2S)-2-((1R,3R,7E)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylene-9,10-secoestra-5,7-dien-17-yl)propyl]-3-{[(2,2-dimethylpropanoyl)oxy]methyl}-3-butenyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (1010389-42-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1016/j.bmc.2007.09.017

Reference yield: 46.5%

2-((2S,4S)-4-{(4E)-4-[2-((3R,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-4-methylenecyclohexylidene)ethylidene]-7a-methyloctahydro-1H-inden-1-yl}-2-hydroxypentyl)-2-propenyl pivalate (1010389-46-4) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → (1S)-1-[(2S)-2-((1R,3R,7E)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylene-9,10-secoestra-5,7-dien-17-yl)propyl]-3-{[(2,2-dimethylpropanoyl)oxy]methyl}-3-butenyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (1010389-44-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1016/j.bmc.2007.09.017

upstream raw materials:

(6S)-6-((1R,3R,7E)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylene-9,10-secoestra-5,7-dien-17-yl)-2-methylene-1,4-heptanediol

pivaloyl chloride

Downstream raw materials:

(1S)-1-[(2S)-2-((1R,3R,7E)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylene-9,10-secoestra-5,7-dien-17-yl)propyl]-3-{[(2,2-dimethylpropanoyl)oxy]methyl}-3-butenyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

(1S)-1-[(2S)-2-((1R,3R,7E)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylene-9,10-secoestra-5,7-dien-17-yl)propyl]-3-{[(2,2-dimethylpropanoyl)oxy]methyl}-3-butenyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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