1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil

Base Information

• Chemical Name: 1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil
• CAS No.: 93503-27-6
• Molecular Formula: C₂₃H₂₆N₂O₄S
• Molecular Weight: 426.536
• Mol file: 93503-27-6.mol

Synonyms:1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil

Chemical Property of 1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil

There total 2 articles about 1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-2-thiouracil (93503-26-5) + methyl iodide (74-88-4) → 1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil (93503-27-6)

Guidance literature:

With sodium hydrogencarbonate; In methanol; for 16h; Ambient temperature;

DOI:10.1021/jm00381a015

Reference yield:

1,3-dibenzyloxy-2-(chloromethoxy)propane (74564-16-2) → 1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil (93503-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / Hg(CN)2 / benzene / 16 h / Ambient temperature

2: 100 percent / NaHCO₃ / methanol / 16 h / Ambient temperature

With mercury(II) cyanide; sodium hydrogencarbonate; In methanol; benzene;

DOI:10.1021/jm00381a015

Reference yield: 60.0%

1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-S-methyl-2-thiouracil (93503-27-6) → 1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}isocytosine (93503-28-7)

Guidance literature:

With ammonia; In methanol; 1.) RT, 16 h, 2.) 50 deg C, 24 h;

DOI:10.1021/jm00381a015

upstream raw materials:

1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}-2-thiouracil

methyl iodide

1,3-dibenzyloxy-2-(chloromethoxy)propane

Downstream raw materials:

1-{[1,3-bis-(benzyloxy)-2-propoxy]methyl}isocytosine