Technology Process of 4-(3-amino-2-methoxyphenyl)furan-2-carboxylic acid
There total 7 articles about 4-(3-amino-2-methoxyphenyl)furan-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium formate;
palladium-on-charcoal;
In
ethyl acetate;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium nitrate; sulfuric acid / water / 2 h / 20 - 25 °C
2.1: potassium carbonate / acetone / 40 h / 70 °C
3.1: potassium acetate / tetrakis(triphenylphosphine) palladium(0) / etheroxalic acid dimethyl ether / 17 h / Reflux
4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / Reflux
4.2: pH 3
5.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3 h / Reflux
With
sodium nitrate; sulfuric acid; ammonium formate; potassium acetate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; etheroxalic acid dimethyl ether; water; ethyl acetate; acetone;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonium hydroxide; zinc; water / 6 h / 20 °C
1.2: pH 3
2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / Reflux
2.2: pH 3
3.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3 h / Reflux
With
ammonium hydroxide; water; ammonium formate; potassium carbonate; zinc;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; water; ethyl acetate;
