methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Chemical Name:methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate
CAS No.:1596341-52-4
Molecular Formula:C₂₂H₁₈ClF₃N₂O₄
Molecular Weight:466.844
Hs Code.:

Synonyms:methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Chemical Property of methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Technology Process of methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

There total 11 articles about methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1596341-51-3
methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596341-52-4
methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: With sodium tetrahydroborate; In diethylene glycol dimethyl ether; at 0 ℃; for 0.75h;

Reference yield:

: 1403382-22-8
ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate

: 1596341-52-4
methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

2.1: methanol / cyclohexane; diethyl ether / 0.25 h / 0 - 20 °C

3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1.5 h / 100 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / diethylene glycol dimethyl ether / 0.75 h / 0 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In 1,4-dioxane; diethyl ether; diethylene glycol dimethyl ether; N,N-dimethyl acetamide; cyclohexane; water; mineral oil;

Reference yield:

: 866615-03-4
1-fluoro-2-(methoxymethoxy)-4-(trifluoro methyl)benzene

: 1596341-52-4
methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

3.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

5.1: methanol / cyclohexane; diethyl ether / 0.25 h / 0 - 20 °C

6.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1.5 h / 100 °C / Inert atmosphere

6.2: 1 h / 20 °C / Inert atmosphere

7.1: sodium tetrahydroborate / diethylene glycol dimethyl ether / 0.75 h / 0 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium tert-butylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; diethylene glycol dimethyl ether; N,N-dimethyl acetamide; cyclohexane; water; mineral oil;