methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Base Information

Chemical Name:methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate
CAS No.:1596341-51-3
Molecular Formula:C₂₂H₁₆ClF₃N₂O₄
Molecular Weight:464.828
Hs Code.:

Synonyms:methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

There total 11 articles about methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 15878-00-9
4-chloro-1H-pyrazole

: 1403382-23-9
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596341-51-3
methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: 4-chloro-1H-pyrazole; methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 100 ℃; for 1.5h; Inert atmosphere;

methylating agent; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: C₂₁H₁₄ClF₃N₂O₄

: 77-78-1
dimethyl sulfate

: 1596341-51-3
methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1403382-22-8
ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate

: 1596341-51-3
methyl 2-[3-(4-chloro-1H-pyrazol-1-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

2.1: methanol / cyclohexane; diethyl ether / 0.25 h / 0 - 20 °C

3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1.5 h / 100 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In 1,4-dioxane; diethyl ether; N,N-dimethyl acetamide; cyclohexane; water; mineral oil;