methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Base Information

Chemical Name:methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate
CAS No.:1403382-23-9
Molecular Formula:C₁₉H₁₄F₄O₄
Molecular Weight:382.311
Hs Code.:

Synonyms:methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

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Chemical Property of methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

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Technology Process of methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

There total 10 articles about methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1596341-32-0
2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 1403382-23-9
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: With methanol; In diethyl ether; cyclohexane; at 0 - 20 ℃; for 0.25h;

Reference yield: 77.0%

: 1002727-88-9
2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1403382-22-8
ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate

: 1403382-23-9
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: 2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 85 ℃;

With diazomethyl-trimethyl-silane; In methanol; diethyl ether; cyclohexane; at 20 ℃; for 0.25h;

With acetic acid; In methanol; diethyl ether; cyclohexane; at 0 ℃;

Reference yield:

: 1403382-20-6
ethyl 2-[3-fluoro-2-(methoxymethoxy)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1403382-23-9
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

2.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C

3.2: 0.25 h / 0 - 20 °C

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water;