2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid

Base Information

Chemical Name:2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid
CAS No.:1400705-52-3
Molecular Formula:C₂₀H₂₄N₂O₃
Molecular Weight:340.422
Hs Code.:

Synonyms:2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid

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Chemical Property of 2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid

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Technology Process of 2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid

There total 7 articles about 2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400705-51-2
2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid methyl ester

: 1400705-52-3
2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid

Guidance literature:: 2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid methyl ester; With lithium hydroxide monohydrate; water; In 1,4-dioxane; for 2h; Reflux;

In 1,4-dioxane; pH=3; buffer;

Reference yield:

: 626-02-8
3-Iodophenol

: 1400705-52-3
2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate; tetrabutyl-ammonium chloride / palladium diacetate / N,N-dimethyl-formamide / 1 h / 70 °C

1.2: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

4.1: Lawessons reagent / xylenes / 3 h / Reflux

5.1: ammonia; ammonium chloride / methanol / 0.67 h / Reflux

6.1: pyridine; acetic acid / methanol / 26 h / Reflux

7.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / Reflux

7.2: pH 3 / buffer

With Lawessons reagent; pyridine; lithium hydroxide monohydrate; tetrabutyl-ammonium chloride; ammonia; water; hydrogen; potassium carbonate; ammonium chloride; acetic acid; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; xylenes;

Reference yield:

: 1400705-30-7
5-(3-hydroxy-phenyl)-4-pentenoic acid ethyl ester

: 1400705-52-3
2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

3.1: Lawessons reagent / xylenes / 3 h / Reflux

4.1: ammonia; ammonium chloride / methanol / 0.67 h / Reflux

5.1: pyridine; acetic acid / methanol / 26 h / Reflux

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / Reflux

6.2: pH 3 / buffer

With Lawessons reagent; pyridine; lithium hydroxide monohydrate; ammonia; water; hydrogen; potassium carbonate; ammonium chloride; acetic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; xylenes;