Melperone

Base Information

• Chemical Name: Melperone
• CAS No.: 3575-80-2
• Molecular Formula: C16H22 F N O
• Molecular Weight: 263.355
• European Community (EC) Number: 609-173-2
• UNII: J8WA3K39B7
• DSSTox Substance ID: DTXSID0023298
• Nikkaji Number: J22.266F
• Wikipedia: Melperone
• Wikidata: Q415972
• NCI Thesaurus Code: C73293
• Metabolomics Workbench ID: 152257
• ChEMBL ID: CHEMBL1531134
• Mol file: 3575-80-2.mol

Synonyms:Buronil;Eunerpan;Harmosin;Libernal;Mel-Puren;Melneurin;Melperomerck;melperon;Melperon AbZ;Melperon AL;Melperon AZU;Melperon beta;melperon FG 5111;Melperon Stada;melperon von ct;Melperon-neuraxpharm;Melperon-ratiopharm;Melperon-RPh;Melperon-TEVA;melperone;methylperon;metylperon;metylperon hydrochloride

Chemical Property of Melperone

Chemical Property:

• Melting Point: 78.0 to 82.0 °C
• Boiling Point: 376.1°Cat760mmHg
• PKA: 9.34±0.10(Predicted)
• Flash Point: 181.3°C
• PSA: 20.31000
• Density: 1.046g/cm³
• LogP: 3.45840
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 263.16854249
• Heavy Atom Count: 19
• Complexity: 279

Purity/Quality:

99.9% ^*data from raw suppliers

Melperone >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F
• Recent ClinicalTrials: Pharmacovigilance in Gerontopsychiatric Patients
• Recent EU Clinical Trials: Pharmacovigilance in children and adolescents:
• Therapeutic Function: Neuroleptic

Technology Process of Melperone

There total 16 articles about Melperone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-methylpiperidin (626-58-4) + 1-(4-fluorophenyl)-4-bromo-1-butanone (40132-01-2) → melperone (3575-80-2)

Guidance literature:

With potassium carbonate; potassium iodide; In toluene; at 125 ℃; for 24h;

DOI:10.1039/d0gc00383b

Reference yield: 86.0%

4-methylpiperidin (626-58-4) + 4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → melperone (3575-80-2)

Guidance literature:

With potassium iodide; In toluene; at 125 ℃; for 25h;

DOI:10.1002/chem.201200580

Reference yield: 82.0%

4-fluorobenzoyl chloride (403-43-0) + 1-(3-chloropropyl)-4-methylpiperidine (42138-35-2) → melperone (3575-80-2)

Guidance literature:

4-fluorobenzoyl chloride; With iodine; magnesium; In tetrahydrofuran; for 1h; Reflux;

1-(3-chloropropyl)-4-methylpiperidine; In tetrahydrofuran; at 0 - 20 ℃; for 1.41667h;

upstream raw materials:

4-methylpiperidin

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-(4-chlorobut-1-yn-1-yl)-4-fluorobenzene

1-(4-fluorophenyl)-4-bromo-1-butanone

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