5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole

Base Information

• Chemical Name: 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole
• CAS No.: 1333118-61-8
• Molecular Formula: C₂₆H₃₁NO₅
• Molecular Weight: 437.536
• Mol file: 1333118-61-8.mol

Synonyms:5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole

Chemical Property of 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole

There total 4 articles about 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

p-methoxyl benzaldoxime (3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9) + 3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2Η-1-benzopyran (1333118-59-4) → 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole (1333118-61-8)

Guidance literature:

With copper(ll) sulfate pentahydrate; chloroamine-T; copper; In water; tert-butyl alcohol;

DOI:10.1016/j.bmc.2011.06.074

Reference yield:

3,4-dihydro-6-methoxy-2,5 ,7,8-tetramethyl-2H-benzopyran-2-methanol (184879-62-7) → 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole (1333118-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 0 - 20 °C

2.1: copper(ll) sulfate pentahydrate; chloroamine-T; copper / water; tert-butyl alcohol

With copper(ll) sulfate pentahydrate; potassium tert-butylate; chloroamine-T; copper; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bmc.2011.06.074

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-methoxyphenyl)-isoxazole (1333118-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / tert-butyl alcohol; water / 20 °C

2: copper(ll) sulfate pentahydrate; copper; sodium hydroxide; chloroamine-T / water / 60 °C / pH 6 / Sonication

With copper(ll) sulfate pentahydrate; hydroxylamine hydrochloride; chloroamine-T; copper; sodium hydroxide; In water; tert-butyl alcohol;

DOI:10.1016/j.ultsonch.2013.05.012

upstream raw materials:

p-methoxyl benzaldoxime

3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2Η-1-benzopyran

3,4-dihydro-6-methoxy-2,5 ,7,8-tetramethyl-2H-benzopyran-2-methanol

3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

Downstream raw materials:

2-{[(3-(4-methoxyphenyl)isoxazol-5-yl)methoxy]methyl}-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol

5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-hydroxyphenyl)isoxazole