5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde

Base Information

Chemical Name:5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde
CAS No.:1309956-58-8
Molecular Formula:C₂₃H₂₁NOS
Molecular Weight:359.492
Hs Code.:

Synonyms:5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde

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Chemical Property of 5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde

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Technology Process of 5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde

There total 1 articles about 5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1250863-85-4
7-bromo-1,2,3,3a,4,8b-hexahydro-4-(4-methylphenyl)-cyclopent-[b]indole

: (5-formylthiophen-2-yl)boronic acid

: 1309956-58-8
5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; for 24h; Reflux; Inert atmosphere;
DOI:10.1039/c1cp20484j

Reference yield: 78.0%

: 1309956-58-8
5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1309956-55-5
trans-2-cyano-3-(5-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophen-2-yl)acrylic acid

Guidance literature:: With piperidine; In acetonitrile; for 6h; Reflux; Inert atmosphere;
DOI:10.1039/c1cp20484j

Reference yield:

: 1309956-58-8
5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde

: 23259-98-5
2-thienylmethyltriphenylphosphonium bromide

: 7-(5-(2-(thiophen-2-yl)vinyl)thiophen-2-yl)-4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole

Guidance literature:: 2-thienylmethyltriphenylphosphonium bromide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

5-(4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)thiophene-2-carbaldehyde; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1039/c1cp20484j