dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:98015-16-8
Molecular Formula:C₂₁H₂₄N₂O₆S₂
Molecular Weight:464.563
Hs Code.:

Synonyms:dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 7 articles about dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 105-45-3
acetoacetic acid methyl ester

: 98015-15-7
2-<1,3-dithian-2-yl>-5-nitrobenzaldehyde

: 14205-39-1
methyl 3-aminocrotonate

: 98015-16-8
dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In methanol; for 24h; Heating;
DOI:10.1021/jo00221a030

Reference yield:

: 21731-17-9
methyl 3-aminocrotonate

: 105-45-3
acetoacetic acid methyl ester

: 98015-15-7
2-<1,3-dithian-2-yl>-5-nitrobenzaldehyde

: 98015-16-8
dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In methanol;

Reference yield:

: 89891-73-6
6-nitro-3-bromo-3H-isobenzofuran-1-one

: 98015-16-8
dimethyl 4-(2-<1,3-dithian-2-yl>-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O / 1 h / Heating

2: 87 percent / BF₃*Et₂O / CHCl₃ / 3 h / Ambient temperature

3: 94 percent / BH₃*THF / Ambient temperature

4: 66 percent / pyridinium chlorochromate / CH₂Cl₂ / 16 h

5: 54 percent / methanol / 24 h / Heating

With borane-THF; boron trifluoride diethyl etherate; water; pyridinium chlorochromate; In methanol; dichloromethane; chloroform;
DOI:10.1021/jo00221a030