methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate

Base Information

Chemical Name:methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate
CAS No.:538335-87-4
Molecular Formula:C₂₉H₃₃N₃O₈
Molecular Weight:551.596
Hs Code.:

Synonyms:methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate

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Chemical Property of methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate

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Technology Process of methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate

There total 8 articles about methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 35356-70-8
Methyl 2-acetamidoacrylate

: 210963-56-7
benzyl (3R)-tert-butoxycarbonylamino-4-(5-cyano-2-iodophenoxy)butyric acid

: 538335-87-4
methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; Heating;
DOI:10.1021/jm020485x

Reference yield:

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 538335-87-4
methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C

2: 5.28 g / aq. NaBH₄ / tetrahydrofuran / 0.05 h / 0 °C

3: 67 percent / N,N,N',N'-tetramethylazodicarboxamide; triphenylphosphine / toluene / 0 °C

4: 79 percent / triethylamine; tri-o-tolylphosphine; Pd(OAc)2 / acetonitrile / Heating

With palladium diacetate; sodium tetrahydroborate; diamide; triethylamine; triphenylphosphine; tris-(o-tolyl)phosphine; In tetrahydrofuran; toluene; acetonitrile; 4: Heck reaction;
DOI:10.1021/jm020485x

Reference yield:

: 182748-72-7
(R)-3-((tert-butoxycarbonyl)amino)-4-hydroxybutyric acid benzyl ester

: 538335-87-4
methyl 2-acetamido-3-[(2-butoxycarbonylcarbonylamino-3-benzyloxycarbonylpropoxy)-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / N,N,N',N'-tetramethylazodicarboxamide; triphenylphosphine / toluene / 0 °C

2: 79 percent / triethylamine; tri-o-tolylphosphine; Pd(OAc)2 / acetonitrile / Heating

With palladium diacetate; diamide; triethylamine; triphenylphosphine; tris-(o-tolyl)phosphine; In toluene; acetonitrile; 2: Heck reaction;
DOI:10.1021/jm020485x