Technology Process of methyl 2-acetamido-3-[2-(2R)-2-[4-(1-tert-butoxycarbonylpiperidyl-4-oxy)benzoylamino-3-benzyloxycarbonylpropoxy]-4-cyanophenyl]acrylate
There total 13 articles about methyl 2-acetamido-3-[2-(2R)-2-[4-(1-tert-butoxycarbonylpiperidyl-4-oxy)benzoylamino-3-benzyloxycarbonylpropoxy]-4-cyanophenyl]acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C
2: 92 percent / aq. NaOH / ethanol / 72 h
3: triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide
With
sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm020485x
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C
2: 5.28 g / aq. NaBH4 / tetrahydrofuran / 0.05 h / 0 °C
3: 67 percent / N,N,N',N'-tetramethylazodicarboxamide; triphenylphosphine / toluene / 0 °C
4: 79 percent / triethylamine; tri-o-tolylphosphine; Pd(OAc)2 / acetonitrile / Heating
5: 100 percent / HCl / dioxane
6: triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide
With
hydrogenchloride; palladium diacetate; sodium tetrahydroborate; diamide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile;
4: Heck reaction;
DOI:10.1021/jm020485x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C
2: 92 percent / aq. NaOH / ethanol / 72 h
3: triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide
With
sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm020485x
