(R)-(+)-2-Phenylbutyronitrile

Base Information

• Chemical Name: (R)-(+)-2-Phenylbutyronitrile
• CAS No.: 82863-69-2
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.204
• Mol file: 82863-69-2.mol

Synonyms:(R)-(+)-2-Phenylbutyronitrile

Chemical Property of (R)-(+)-2-Phenylbutyronitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-2-Phenylbutyronitrile

There total 19 articles about (R)-(+)-2-Phenylbutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenylbutanenitrile (769-68-6) → (R)-(+)-2-Phenylbutyronitrile (82863-69-2) + (S)-2-phenylbutyric acid (4286-15-1) + (2R)-2-phenylbutanoic acid (938-79-4) + (S)-2-phenyl-butyronitrile (56652-56-3)

Guidance literature:

With Rhodococcus erythropolis SET₁ cells; In aq. phosphate buffer; at 25 ℃; pH=7; enantioselective reaction; Microbiological reaction;

DOI:10.1002/ejoc.201403201

Reference yield:

1-phenylpropene (637-50-3) + trimethylsilyl cyanide (7677-24-9) → (R)-(+)-2-Phenylbutyronitrile (82863-69-2) + (S)-2-phenyl-butyronitrile (56652-56-3)

Guidance literature:

With 1,1,2,2-tetramethyl-1,2-ethanediamino-N,N'-bis(3,5-di-tert-butylsalicylidene)-cobalt(II); phenylsilane; tetrabutylammonium tetrafluoroborate; C₁₉H₂₈N₂O₆; copper(II) bis(trifluoromethanesulfonate); acetic acid; In N,N-dimethyl-formamide; at 0 ℃; Overall yield = 81 percent; enantioselective reaction; Electrolysis; Inert atmosphere; Sealed tube;

DOI:10.1038/s41557-020-0469-5

Reference yield:

2-phenylbutanenitrile (769-68-6) → (R)-(+)-2-Phenylbutyronitrile (82863-69-2) + (S)-2-phenyl-butyronitrile (56652-56-3)

Guidance literature:

With [Co₂((S)-mandelate)₂(4,4'-bipyridine)₃](NO₃)₂ coated capillary column; at 150 ℃; for 0.0416667h; Reagent/catalyst; Resolution of racemate;

DOI:10.1016/j.chempr.2017.07.004

upstream raw materials:

(R)-(-)-2-phenylbutyramide

(R)-(-)-2-phenylbutyric acid chloride

(Z)-2-phenylbut-2-enenitrile

1-(1,1-dimethylethyl)-1,1-dimethyl-N-(2-phenyl-1-propen-1-ylidene)silanamine