3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide

Base Information

• Chemical Name: 3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide
• CAS No.: 504414-04-4
• Molecular Formula: C₂₁H₂₇NO₂Si
• Molecular Weight: 353.536
• Mol file: 504414-04-4.mol

Synonyms:3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide

Chemical Property of 3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide

There total 5 articles about 3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzylamine (100-46-9) + (3RS)-3-dimethyl(phenyl)silyl-5-oxo-hexanoic acid (504413-95-0) → 3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide (504414-04-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/S0040-4039(02)02319-5

Reference yield:

dimethyl(phenyl)silyllithium (3839-31-4) → 3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide (504414-04-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 77 percent / tetrahydrofuran / -78 - 0 °C

2: 100 percent / Et₂NH / 20 °C

3: 61 percent / NaCl / H₂O; dimethylsulfoxide / 125 - 160 °C

4: 100 percent / NaOH / methanol; H₂O

5: 85 percent / DCCI; DMAP / CH₂Cl₂

With dmap; sodium hydroxide; diethylamine; dicyclohexyl-carbodiimide; sodium chloride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; 2: Michael addition / 3: Krapcho decarboxylation;

DOI:10.1016/S0040-4039(02)02319-5

Reference yield:

ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate (130247-53-9) → 3-(dimethyl-phenyl-silanyl)-5-oxo-hexanoic acid benzylamide (504414-04-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / Et₂NH / 20 °C

2: 61 percent / NaCl / H₂O; dimethylsulfoxide / 125 - 160 °C

3: 100 percent / NaOH / methanol; H₂O

4: 85 percent / DCCI; DMAP / CH₂Cl₂

With dmap; sodium hydroxide; diethylamine; dicyclohexyl-carbodiimide; sodium chloride; In methanol; dichloromethane; water; dimethyl sulfoxide; 1: Michael addition / 2: Krapcho decarboxylation;

DOI:10.1016/S0040-4039(02)02319-5

upstream raw materials:

benzylamine

(3RS)-3-dimethyl(phenyl)silyl-5-oxo-hexanoic acid

dimethyl(phenyl)silyllithium

ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate