5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde

Base Information

Chemical Name:5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde
CAS No.:905441-58-9
Molecular Formula:C₁₇H₂₆N₂O₂
Molecular Weight:290.406
Hs Code.:

Synonyms:5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde

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Chemical Property of 5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde

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Technology Process of 5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde

There total 4 articles about 5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109-01-3
1-methyl-piperazine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 2725-53-3
2-hydroxy-5-t-butylbenzaldehyde

: 905441-58-9
5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde

Guidance literature:: In ethanol; for 72h; Heating;
DOI:10.1016/j.tet.2005.03.117

Reference yield:

: 109-01-3
1-methyl-piperazine

: 3-(chloromethyl)-5-(tert-butyl)-2-hydroxybenzaldehyde

: 905441-58-9
5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde

Guidance literature:: With potassium iodide; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol401065r

Reference yield:

: 2725-53-3
2-hydroxy-5-t-butylbenzaldehyde

: 905441-58-9
5-(tert-butyl)-2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 48 h / 20 °C / Inert atmosphere

2: potassium iodide / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium iodide; In water; ethyl acetate;
DOI:10.1021/ol401065r