Dexlofexidine

Base Information

Chemical Name:Dexlofexidine
CAS No.:81447-79-2
Molecular Formula:C11H12Cl2N2O
Molecular Weight:259.135
Hs Code.:
Mol file:81447-79-2.mol

Synonyms:2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline;(-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene;Lofexidina;Lofexidinum [INN-Latin];rac-lofexidine;rac-2-[1-(2,6-dichlorophenoxy)ethyl]-1,3-diazacyclopent-2-ene;Britlofex;Lofexidine;Lofexidinum;Lofexidine [INN:BAN];Lofexidina [INN-Spanish];

Suppliers and Price of Dexlofexidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-Lofexidine
2.5mg
$ 130.00

American Custom Chemicals Corporation
(S)-LOFEXIDINE 95.00%
10MG
$ 1871.10

American Custom Chemicals Corporation
(S)-LOFEXIDINE 95.00%
5MG
$ 1851.30

American Custom Chemicals Corporation
(S)-LOFEXIDINE 95.00%
1MG
$ 739.20

Total 4 raw suppliers

Chemical Property of Dexlofexidine

Chemical Property:

PSA：33.62000
LogP:2.52680

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

(S)-Lofexidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (S)-Lofexidine is the S-enantiomer of Lofexidine,a 2-Adrenoceptor agonist related structurally to Clonidine.(S)-Lofexidine is Used in treatment of opioid withdrawal symptoms; antihypertensive.

Technology Process of Dexlofexidine

There total 16 articles about Dexlofexidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 344559-34-8,86981-78-4
(±)ethyl 2-(2,6-dichlorophenoxy)propionate

: 107-15-3,85404-18-8
ethylenediamine

: 73372-53-9,81447-78-1,81447-79-2,31036-80-3
lofexidine

Guidance literature:: ethylenediamine; With titanium(IV) isopropylate; In toluene; at 20 ℃; for 1h; Inert atmosphere;

(±)ethyl 2-(2,6-dichlorophenoxy)propionate; In toluene; at 110 ℃; for 18h; Time; Inert atmosphere;