(4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline

Base Information

• Chemical Name: (4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline
• CAS No.: 1055309-70-0
• Molecular Formula: C₂₂H₁₉NO₂
• Molecular Weight: 329.398
• Mol file: 1055309-70-0.mol

Synonyms:(4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline

Chemical Property of (4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline

There total 1 articles about (4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-3-methoxybenzamide (1055309-69-7) → (4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline (1055309-70-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); diisopropyl-carbodiimide; In 1,4-dioxane; at 120 ℃; for 17h;

DOI:10.1002/anie.200801078

Reference yield: 54.0%

(4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline (1055309-70-0) + isopropyllithium (1888-75-1) + methyl iodide (74-88-4) → C23H21NO2 (1055309-80-2) + (4R,5R)-2-((1S,6S)-6-isopropyl-5-methoxy-1-methylcyclohexa-2,4-dienyl)-4,5-diphenyloxazoline, (1055309-79-9)

Guidance literature:

(4R,5R)-2-(3-methoxyphenyl)-4,5-diphenyloxazoline; isopropyllithium; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; pentane; at -78 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1002/anie.200801078

upstream raw materials:

N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-3-methoxybenzamide

Downstream raw materials:

C₂₃H₂₁NO₂

(4R,5R)-2-((1S,6S)-6-isopropyl-5-methoxy-1-methylcyclohexa-2,4-dienyl)-4,5-diphenyloxazoline,