ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate

Base Information

Chemical Name:ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate
CAS No.:857941-17-4
Molecular Formula:C₂₂H₃₂N₂O₆S
Molecular Weight:452.572
Hs Code.:

Synonyms:ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate

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Chemical Property of ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate

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Technology Process of ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate

There total 1 articles about ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 239101-33-8
deferitrin

: 857941-17-4
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / DIEA / dimethylformamide / 15 h / 20 °C

2: 55 percent / NaOEt / ethanol / 15 h / 75 °C

With sodium ethanolate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm048974f

Reference yield:

: 857941-17-4
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate

: 857941-18-5
(S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1021/jm048974f

Reference yield:

: 857941-17-4
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate

: (S)-4,5-dihydro-2-[2-hydroxy-4-(4-aminobutoxy)phenyl]-4-methyl-4-thiazolecarboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / ethanol / 20 °C

2: 0.331 g / CH₂Cl₂ / 2 h / 0 - 20 °C

With sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1021/jm048974f