(20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

Base Information

Chemical Name:(20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate
CAS No.:849791-80-6
Molecular Formula:C₂₈H₃₉NO₆S
Molecular Weight:517.687
Hs Code.:

Synonyms:(20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

Suppliers and Price of (20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

Chemical Property:

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Technology Process of (20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

There total 4 articles about (20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-63-0
methanesulfonyl chloride

: 849791-79-3
(E,20R)-3β-hydroxy-6-oximino-7-nor-5α-pregnan-20-yl benzoate

: 849791-80-6
(20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

Guidance literature:: With pyridine; at 0 ℃; for 4h;
DOI:10.1016/j.tet.2005.01.055

Reference yield:

: 251984-45-9
(20R)-7-Norpregn-5-ene-3β,20-diyl 3-acetate 20-benzoate

: 849791-80-6
(20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / perchloric acid; N-bromo acetamide / dioxane / 1 h / 15 °C

2: 97 percent / potassium carbonate / methanol; H₂O / 20 h / 20 °C

3: 64 percent / BF₃*Et₂O / tetrahydrofuran; diethyl ether / 20 h / 20 °C

4: 52 percent / potassium hydrogen carbonate; hydroxylamine hydrochloride / methanol / 5 h / Heating

5: 97 percent / pyridine / 4 h / 0 °C

With pyridine; perchloric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; potassium carbonate; potassium hydrogencarbonate; N-bromoacetamide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; 5: Beckmann rearrangement;
DOI:10.1016/j.tet.2005.01.055

Reference yield:

: 849791-76-0
(20R)-5,6β-epoxy-3β-hydroxy-7-nor-5β-pregnan-20-yl benzoate

: 849791-80-6
(20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / BF₃*Et₂O / tetrahydrofuran; diethyl ether / 20 h / 20 °C

2: 52 percent / potassium hydrogen carbonate; hydroxylamine hydrochloride / methanol / 5 h / Heating

3: 97 percent / pyridine / 4 h / 0 °C

With pyridine; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; potassium hydrogencarbonate; In tetrahydrofuran; methanol; diethyl ether; 3: Beckmann rearrangement;
DOI:10.1016/j.tet.2005.01.055