di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate

Base Information

• Chemical Name: di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate
• CAS No.: 1372716-19-2
• Molecular Formula: C₄₆H₅₂N₂O₆P₂
• Molecular Weight: 790.876
• Mol file: 1372716-19-2.mol

Synonyms:di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate

Chemical Property of di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate

There total 2 articles about di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine (1059631-10-5) + (S,S)-(-)-1-r-oxo-2-c,5-t-diphenylphospholane (474093-57-7) → di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate (1372716-19-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 2h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201101293

Reference yield:

di-tert butyl-2,5-dioxopiperzine-1,4-dicarboxylate (151692-07-8) → di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate (1372716-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Basic conditions

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide;

DOI:10.1002/ejoc.201101293

upstream raw materials:

N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine

(S,S)-(-)-1-r-oxo-2-c,5-t-diphenylphospholane

di-tert butyl-2,5-dioxopiperzine-1,4-dicarboxylate