(1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide

Base Information

• Chemical Name: (1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide
• CAS No.: 92264-18-1
• Molecular Formula: BrH*C₁₈H₂₁NO
• Molecular Weight: 348.283
• Mol file: 92264-18-1.mol

Synonyms:(1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide

Chemical Property of (1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide

There total 4 articles about (1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1S,3R)-2-Benzyl-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline (92264-17-0,109463-55-0) → (1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide (92264-18-1)

Guidance literature:

In hydrogen bromide; Heating;

DOI:10.1016/S0040-4039(01)81225-9

Reference yield:

8-Methoxy-1,3-dimethyl-isoquinoline; hydrobromide (82958-26-7) → (1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide (92264-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / hydrogen, HClO₄ / PtO₂ / methanol

2: 85 percent / K₂CO₃ / propan-1-ol

3: 94 percent / aq. HBr / Heating

With perchloric acid; hydrogen; potassium carbonate; platinum(IV) oxide; In methanol; propan-1-ol; hydrogen bromide;

DOI:10.1016/S0040-4039(01)81225-9

Reference yield:

benzyl bromide (100-39-0) → (1S,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol; hydrobromide (92264-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃ / propan-1-ol

2: 94 percent / aq. HBr / Heating

With potassium carbonate; In propan-1-ol; hydrogen bromide;

DOI:10.1016/S0040-4039(01)81225-9

upstream raw materials:

(1S,3R)-2-Benzyl-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline

benzyl bromide

(1S,3R)-8-Methoxy-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline

8-Methoxy-1,3-dimethyl-isoquinoline; hydrobromide

Downstream raw materials:

(2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

(1S,3R)-2-Benzyl-7-(4,5-dimethoxy-2-methyl-naphthalen-1-yl)-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol

(1S,3R)-2-Benzyl-8-(1-bromo-4,5-dimethoxy-naphthalen-2-ylmethoxy)-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline