3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid

Base Information

Chemical Name:3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid
CAS No.:224633-12-9
Molecular Formula:C₁₉H₁₈N₂O₂
Molecular Weight:306.364
Hs Code.:

Synonyms:3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid

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Chemical Property of 3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid

Chemical Property:

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Technology Process of 3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid

There total 6 articles about 3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 43071-45-0
3-methyl-2-phenylquinoline-4-carboxylic acid

: 224633-12-9
3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl chloride / CH₂Cl₂ / 0.5 h / 20 °C

1.2: DMF / CH₂Cl₂ / 0.5 h

2.1: CH₂Cl₂ / 18 h

3.1: 70 percent / NBS; dibenzoylperoxide / acetonitrile / 28 h / Heating

4.1: iPr₂NEt / tetrahydrofuran / 50 °C

5.1: aq. HCl / 4 h / Heating

With hydrogenchloride; N-Bromosuccinimide; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm000501v

Reference yield:

: 174636-71-6
3-methyl-2-phenylquinoline-4-carbonyl chloride

: 224633-12-9
3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 18 h

2: 70 percent / NBS; dibenzoylperoxide / acetonitrile / 28 h / Heating

3: iPr₂NEt / tetrahydrofuran / 50 °C

4: aq. HCl / 4 h / Heating

With hydrogenchloride; N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm000501v

Reference yield:

: 74960-43-3
3-methyl-2-phenyl-quinoline-4-carboxylic acid methyl ester

: 224633-12-9
3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NBS; dibenzoylperoxide / acetonitrile / 28 h / Heating

2: iPr₂NEt / tetrahydrofuran / 50 °C

3: aq. HCl / 4 h / Heating

With hydrogenchloride; N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm000501v