2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

Base Information

• Chemical Name: 2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine
• CAS No.: 945403-81-6
• Molecular Formula: C₄₅H₆₆N₈O₈Si₂
• Molecular Weight: 903.239
• Mol file: 945403-81-6.mol

Synonyms:2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

Chemical Property of 2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

There total 1 articles about 2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-Benzyloxycarbonyl-L-isoleucyl-L-phenylalanin (13254-07-4) + 2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine (160056-49-5) → 2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine (945403-81-6)

Guidance literature:

N-Benzyloxycarbonyl-L-isoleucyl-L-phenylalanin; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine; In dichloromethane; at 20 ℃; Further stages.;

DOI:10.1016/j.tet.2007.04.038

Reference yield:

2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine (945403-81-6) → 2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxyadenosine (945403-82-7)

Guidance literature:

With ammonium fluoride; In methanol; at 20 ℃;

DOI:10.1016/j.tet.2007.04.038

Reference yield:

2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine (945403-81-6) → 2'-N-(L-isoleucyl-L-phenylalanyl)-amino-2'-deoxyadenosine

Guidance literature:

Multi-step reaction with 2 steps

1: 117 mg / ammonium fluoride / methanol / 20 °C

2: 94 percent / hydrogen / palladium on carbon / methanol / 20 °C

With ammonium fluoride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.tet.2007.04.038

upstream raw materials:

N-Benzyloxycarbonyl-L-isoleucyl-L-phenylalanin

2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

Downstream raw materials:

2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxyadenosine