8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Base Information

Chemical Name:8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one
CAS No.:956235-67-9
Molecular Formula:C₄₅H₆₅N₃O₅SSi
Molecular Weight:788.18
Hs Code.:

8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Synonyms:8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

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Chemical Property of 8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

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Technology Process of 8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

There total 13 articles about 8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.7%

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 956235-66-8
6-{2-[[3-(cyclopentylsulfinyl)benzyl](methyl)amino]ethoxy}hexan-1-amine

: 956235-67-9
8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: With sodium hydrogencarbonate; sodium iodide; In dimethyl sulfoxide; at 120 ℃; for 1h;

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 956235-67-9
8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / tetrabutylammomium bromide / water / 5 h / 20 °C

2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 3 h / 75 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2070.21 Torr

4: triethylamine / dichloromethane / 20 °C

5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 17 h / 70 °C

6: sodium periodate / methanol; water / 18 h / 20 °C

7: hydrazine / ethanol / 4 h / 60 °C

8: sodium hydrogencarbonate / sodium iodide / dimethyl sulfoxide / 1 h / 120 °C

With sodium hydroxide; sodium periodate; hydrogen; sodium hydrogencarbonate; triethylamine; hydrazine; palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide; sodium iodide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 956235-63-5
[3-(cyclopentylthio)benzyl]methylamine

: 956235-67-9
8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[[3-(cyclopentyl-sulfinyl)benzyl](methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 17 h / 70 °C

2: sodium periodate / methanol; water / 18 h / 20 °C

3: hydrazine / ethanol / 4 h / 60 °C

4: sodium hydrogencarbonate / sodium iodide / dimethyl sulfoxide / 1 h / 120 °C

With sodium periodate; sodium hydrogencarbonate; hydrazine; sodium iodide; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;