4-bromo-4α-fluorodiphenylmethane

Base Information

• Chemical Name: 4-bromo-4α-fluorodiphenylmethane
• CAS No.: 17100-44-6
• Molecular Formula: C₁₃H₁₀BrF
• Molecular Weight: 265.125
• Mol file: 17100-44-6.mol

Synonyms:4-bromo-4α-fluorodiphenylmethane

Chemical Property of 4-bromo-4α-fluorodiphenylmethane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-bromo-4α-fluorodiphenylmethane

There total 13 articles about 4-bromo-4α-fluorodiphenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tris(4-fluorophenyl)bismuthane (437-29-6) + p-bromobenzyl chloride (589-17-3) → 4-bromo-4α-fluorodiphenylmethane (17100-44-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 2h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/c3ra46672h

Reference yield: 82.0%

4-bromo-benzaldehyde (1122-91-4) + 4-flourophenylmagnesium bromide (352-13-6) → 4-bromo-4α-fluorodiphenylmethane (17100-44-6)

Guidance literature:

4-bromo-benzaldehyde; 4-flourophenylmagnesium bromide; In tetrahydrofuran;

With triethylsilane; trifluoroacetic acid;

DOI:10.1016/S0960-894X(99)00516-8

Reference yield: 80.0%

tris(4-fluorophenyl)bismuthane (437-29-6) + 1-bromomethyl-4-bromobenzene (589-15-1) → 4-bromo-4α-fluorodiphenylmethane (17100-44-6)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl acetamide; at 90 ℃; for 1h; chemoselective reaction;

DOI:10.1039/c3ra40413g

upstream raw materials:

4-bromo-benzaldehyde

4-flourophenylmagnesium bromide

4-bromo-4'-fluorodiphenylmethanol

4-fluoroboronic acid

Downstream raw materials:

(4-bromophenyl)-(4-fluorophenyl)methanone

C₁₅H₁₃F

(Z)-1-[4-(4-fluorobenzyl)phenyl]prop-1-ene

4-[4-(4-fluorobenzyl)phenyl]-4-piperidinol