1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane

Base Information

Chemical Name:1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane
CAS No.:153943-18-1
Molecular Formula:C₃₃H₄₀N₂O₃Si
Molecular Weight:540.778
Hs Code.:

Synonyms:1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane

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Chemical Property of 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane

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Technology Process of 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane

There total 7 articles about 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153943-08-9
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-propanol

: 153943-18-1
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane

Guidance literature:: With 1H-imidazole; In acetonitrile; for 3h; Ambient temperature;
DOI:10.1021/jo00080a015

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 153943-18-1
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / NaH / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) 0 deg C to room temp., 3 h; 75 deg C, 16 h

2: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, room temp., 24 h

3: 1.) vinylmagnesium bromide / 1.) THF, 0 deg C to room temp., 1 h, 2.) THF, reflux, 4 h

4: 99.6 percent / H₂ / Raney nickel / ethanol; tetrahydrofuran / 3 h / 760 Torr

5: 99 percent / NaBH₄ / ethanol; tetrahydrofuran / 4.5 h

6: 90 percent / imidazole / acetonitrile / 3 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; vinyl magnesium bromide; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole; nickel; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00080a015

Reference yield:

: 14178-18-8
2-(Benzyloxy)nicotinic acid

: 153943-18-1
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-1-((dimethyl(1,1-dimethylethyl)silyl)oxy)propane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, room temp., 24 h

2: 1.) vinylmagnesium bromide / 1.) THF, 0 deg C to room temp., 1 h, 2.) THF, reflux, 4 h

3: 99.6 percent / H₂ / Raney nickel / ethanol; tetrahydrofuran / 3 h / 760 Torr

4: 99 percent / NaBH₄ / ethanol; tetrahydrofuran / 4.5 h

5: 90 percent / imidazole / acetonitrile / 3 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; vinyl magnesium bromide; hydrogen; 1,1'-carbonyldiimidazole; nickel; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jo00080a015