tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

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Chemical Name:tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate
CAS No.:1333405-32-5
Molecular Formula:C₂₅H₃₄BrN₅O₃
Molecular Weight:532.481
Hs Code.:

Synonyms:tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

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Chemical Property of tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

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Technology Process of tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

There total 6 articles about tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1333405-31-4
3-benzyl-6-bromo-2-(1-bromopropyl)-5-methylpyrrolo[2,3-e]pyrimidin-4-one

: 75178-96-0
N-Boc-1,3-diaminopropane

: 1333405-32-5
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 120h;
DOI:10.1021/jm200629m

Reference yield:

: 1333405-26-7
ethyl 3-(butanoylamino)-1-methylpyrrole-2-carboxylate

: 1333405-32-5
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / 6 h / 110 - 115 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / toluene / 16 h / Reflux

2.2: 0.08 h / 65 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.75 h / Reflux

4.1: triethylamine / dichloromethane / 120 h / 25 °C

With ammonium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm200629m

Reference yield:

: 1333405-25-6
ethyl 3-(butanoylamino)-1H-pyrrole-2-carboxylate

: 1333405-32-5
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzyl tri-n-butylammonium bromide; sodium hydroxide / dichloromethane / 3 h / 0 - 25 °C

2.1: ammonium hydroxide / 6 h / 110 - 115 °C

3.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / toluene / 16 h / Reflux

3.2: 0.08 h / 65 °C

4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.75 h / Reflux

5.1: triethylamine / dichloromethane / 120 h / 25 °C

With ammonium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetra(n-butyl)ammonium hydrogensulfate; benzyl tri-n-butylammonium bromide; potassium carbonate; triethylamine; sodium hydroxide; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm200629m